Induced Suppression of Platelet Activity in Aneurysmal Subarachnoid Hemorrhage Management-2 (iSPASM-2)

Inclusion: * Age 18-85 * Baseline Modified Rankin Scale (mRS) 0-3 (pre-SAH) * SAH attributed to ruptured cerebral aneurysm * Admission Computed Tomography (CT) scan shows Modified Fisher grade 1-4 due to aSAH primarily in the supratentorial space * World Federation of Neurosurgical Societies (WFNS) scale grade ≤4 at randomization * Onset of symptoms of aSAH (ictus) occurred \<72 hours prior to presentation * If External Ventricular Drain (EVD) placed, placement is ≥12 hours prior to enrollment * All aneurysm(s) suspected to be responsible for the hemorrhage must be secured via Endovascular Coil Embolization with a post-embolization Raymond-Roy Score of 1 (Complete) or 2 (Residual Neck) prior to enrollment * Participant can be randomized within 48 hours of aneurysm treatment * Participant or participant's legally-authorized representative (LAR) has provided documented informed consent Exclusion: * Angio-negative SAH, defined as a SAH with a digital subtraction angiogram that does not show an intracranial aneurysm * Surgical clipping prior of the ruptured aneurysm or any non-ruptured aneurysm on the same admission to enrollment * Remaining untreated aneurysm(s) that could reasonably be considered a possible alternate cause of the aSAH based on the observed bleeding pattern * Uncontrollable hypertension (\>180 systolic and/or \>110 diastolic) that is not correctable prior to enrollment * Active internal bleeding, or history of bleeding diathesis, major surgical procedure, or …