CompletedNot Applicable

Er,Cr:YSGG Laser Versus Conventional Preparation for Minimally Invasive Caries Removal

Bulgaria32 participantsStarted 2025-10-23

Plain-language summary

This study compared two standard methods for minimally invasive caries removal in children: conventional mechanical excavation and Er,Cr:YSGG laser preparation. The study aimed to evaluate the reduction of Streptococcus mutans and Lactobacillus spp. in dentin using PCR analysis. All procedures were performed as part of routine dental care, and written informed consent was obtained from parents or legal guardians.

Who can participate

Age range

8 Years – 15 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Lesions located in the inner half of dentin, with a visible cavity or extensive dentin lesion (≥1 mm, measured with a periodontal graded probe) * Negative response to percussion * Absence of pulpal symptoms or spontaneous/night pain * Permanent molars or premolars fully erupted Exclusion Criteria: * Lesions involving less than half of the dentin or without a visible cavity * Teeth with significant crown destruction (ICDAS 06) * Positive response to percussion, pulpal symptoms, spontaneous/night pain * Teeth with periapical changes

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Change in levels of S. mutans and Lactobacillus spp. in dentin samples.

Timeframe: Before and immediately after caries removal

Change in levels of S. mutans and Lactobacillus spp. in dentin samples

Timeframe: Before and immediately after caries removal

Trial details

NCT IDNCT07493278

SponsorMedical University of Sofia

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-02-04

View on ClinicalTrials.gov More Dental Caries trials