Transpulmonary Pressure-guided Mechanical Ventilation Strategy in Right Ventricular Protection in… (NCT07490925) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Transpulmonary Pressure-guided Mechanical Ventilation Strategy in Right Ventricular Protection in Patients With ARDS
180 participantsStarted 2026-04-01
Plain-language summary
To verify whether the transpulmonary pressure-guided mechanical ventilation strategy can reduce right ventricular involvement, especially the incidence of acute cor pulmonale (ACP), in patients with moderate to severe ARDS induced by pneumonia compared with the currently widely used right ventricular protective mechanical ventilation strategy.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Age ≥ 18 years old
. ARDS caused by pneumonia (New Global Definition of ARDS)
. History of pulmonary hypertension caused by various reasons
. Severe arrhythmia
. BMI\>30kg/m2
. Contraindications to inserting an esophageal catheter (including recent esophageal injury or surgery, severe coagulopathy (platelets \< 5×10⁹/L or INR \> 4)
. Pregnant and lactating women
. Lung transplant recipient
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial is focused on protecting the right side of the heart during mechanical ventilation for ARDS — can you explain how right ventricular involvement is currently a concern in my situation and whether monitoring it more closely could matter for my care?
2The trial uses something called transpulmonary pressure to guide how the ventilator is set — how is this different from how ventilator settings are currently managed for me, and what would change day-to-day if I were enrolled?
3Since this trial hasn't started recruiting yet, what does my treatment look like right now while waiting to see if and when the study opens, and is there a standard-of-care approach you'd recommend in the meantime?
4The study is specifically for moderate or severe ARDS — given where my condition currently falls on that spectrum, is this trial even something worth keeping on my radar, or are there other options more relevant to my situation right now?
5Because this trial is listed as phase NA and is still not yet recruiting, how much will be known about the safety of the transpulmonary pressure-guided approach by the time it opens, and how would you weigh that uncertainty against the potential benefit for me?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Incidence of right ventricular involvement within 28 days