Active — Not RecruitingPhase 4

Microbiological Effect of 0.12% Chlorhexidine Digluconate and 0.05% Cetylpyridinium Chloride vs Probiotics (Lactobacillus Reuteri Prodentis) on Porphyromonas Gingivalis.

Mexico20 participantsStarted 2023-01-08

Plain-language summary

This randomized non-inferiority clinical trial aims to evaluate the microbiological effect of 0.12% chlorhexidine and 0.05% cetylpyridinium vs. probiotics (Lactobacillus reuteri Prodentis) on Porphyromonas gingivalis in patients with periodontal disease and diabetes mellitus in Colima, where molecular biology tests such as qPCR will be performed at the end, before and after treatment in each of the groups.

Who can participate

Age range35 Years – 75 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * • Previous diagnosis of controlled type 2 diabetes mellitus. * Periodontal disease (≥2 quadrants affected; probing depth ≥4 mm; bleeding on probing \>10%). * Patients affiliated with the Unidad de Salud Zona Oriente (IMSS-BIENESTAR). * Signed informed consent. Exclusion Criteria: * Inability to cooperate. * Antibiotic treatment within the last 3 months. * Soft tissue pathologies not related to periodontal disease. Elimination Criteria: * Failure to complete the study. * Insufficient or non-extracted DNA sample. * Indication of antibiotics/fluoxetine during the intervention.

What they're measuring

Porphyromonas gingivalis bacteria

Timeframe: 30 days

Trial details

NCT IDNCT07489924

SponsorUniversidad de Colima

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-07-31

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