Efficacy of Behavioral Therapy for Chronic Refractory Cough (NCT07488598) | Clinical Trial Compass
RecruitingNot Applicable
Efficacy of Behavioral Therapy for Chronic Refractory Cough
Egypt30 participantsStarted 2026-03-10
Plain-language summary
Chronic cough is defined as cough persisting for more than eight weeks. It is a common clinical problem that significantly impairs patients' physical, psychological, and social quality of life. Chronic cough remains a diagnostic and therapeutic challenge despite systematic evaluation and treatment of common etiologies such as asthma, gastroesophageal reflux disease
Who can participate
Age range18 Years – 50 Years
SexALL
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Inclusion Criteria:
* Eligible participants are adults aged ≥18 years i.e. normal chest radiograph.
* participants with chronic cough persisting for more than eight weeks that is refractory to standard medical treatment for common causes of chronic cough, including asthma, gastroesophageal reflux disease .
* Participants are required to exhibit clinical features suggestive of laryngeal hyperresponsiveness, such as cough triggered by phonation, laughter, cold air, or irritant exposure, with associated laryngeal symptoms including throat irritation, dysphonia, or frequent throat clearing.
Exclusion Criteria:
* Patients are excluded if they are current smokers or had ceased smoking within six months
* patients have evidence of active pulmonary or cardiac disease, recent respiratory tract infection, recent angiotensin-converting enzyme inhibitor use.
* significant structural laryngeal pathology, neurological disorders affecting cough reflex control, or inability to comply with study procedures.
* Head \&neck pathology e.g sinusitis, glottal insufficiency or primary muscle tension dysphonia