RecruitingNot Applicable

Diagnostic Value and Safety of Combined Biopsy for Mediastinal Metastasis of Lung Cancer

China240 participantsStarted 2026-03-20

Plain-language summary

The study is aimed o evaluate the diagnostic performance and treatment guidance of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) combined with transbronchial mediastinal cryobiopsy (EBUS-TBMCB) in patients with mediastinal metastases of lung cancer.

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. Aged ≥18 years;
✓. Presence of at least one mediastinal lesion (short-axis diameter ≥10 mm) confirmed by thin-slice chest CT;
✓. Patients who have not undergone prior mediastinal biopsy and require further mediastinal biopsy to confirm etiology or pathological subtype, meeting at least one of the following criterias:

Exclusion criteria

✕. Presence of severe cardiopulmonary disease, coagulation disorders, massive hemoptysis, poor tolerance to anesthesia, or other contraindications related to bronchoscopy;
✕. Intraoperative endobronchial ultrasound exploration of the lesion failed to detect the target lesion despite \> 20 minutes of attempts;
✕. Lesions identified as abscesses or cysts;
✕. Presence of mental illness, severe neurosis, or other conditions that preclude the provision of informed consent;
✕. Patients who have participated in other clinical trials within 3 months;
✕. Any other conditions considered to be inappropriate to be involved in this trial.

What they're measuring

Diagnostic yield for lung cancer

Timeframe: From the date of biopsy sample acquisition to the date of follow-up completion, approximately 12 months

Trial details

NCT IDNCT07488507

SponsorThird Military Medical University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2030-03-01

Contact for this trial

Hanbing Wang

+86 18885230175 18885230175@163.com

View on ClinicalTrials.gov More Mediastinal Metastases of Lung Cancer trials