RecruitingNot Applicable

Multi Disciplinary Sickle Cell Disease Obstetrics Care Program in Ghana

Ghana198 participantsStarted 2026-01-22

Plain-language summary

The goal of this observational study is to determine the feasibility and effectiveness of initiating a multidisciplinary sickle cell disease (SCD) obstetrics program for women with SCD in a non-academic hospital. The main question it aims to answer is: In a before-and-after study design, we will test the hypothesis that multidisciplinary care for pregnant women with SCD in a non-academic hospital will result in a 50% relative risk reduction in mortality compared to the mortality rate in pregnant women with SCD in the same hospital before the multidisciplinary care. Participants will be managed using the academic hospital's multidisciplinary sickle cell disease obstetrics protocol adapted for the non-academic hospital

Who can participate

Age range18 Years – 45 Years

SexFEMALE

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Inclusion criteria * Pregnant women with a confirmed laboratory diagnosis of sickle cell disease * Pregnancy confirmed by a pelvic ultrasound scan * Pregnancy should be 34 weeks' gestation or less * Pregnant women should be aged 18 - 45 years * Pregnant women should be attendants at the non-academic hospital Exclusion criteria * All pregnant women with sickle cell disease who do not provide informed consent * All pregnant women with sickle cell disease who are referred for management of acute complications and hospital admission * All pregnant women with sickle cell disease who are referred for labor and delivery * All pregnant women with SCD who plan on delivering outside the non-academic hospital and won't be able to adhere to the follow-up procedures during the puerperium (the first six weeks after childbirth)

What they're measuring

Maternal mortality

Timeframe: Up to 40 weeks for each participant

Trial details

NCT IDNCT07488091

SponsorUniversity of Ghana Medical School

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2028-01-15

Contact for this trial

Dr. Eugenia Vicky N. K. Asare, Senior Specialist Hematologist, MBChB

+233 542354386 / 233 302660762 evnkasare@ug.edu.gh