This retrospective observational study aims to develop treatment-specific machine learning models for predicting tooth-level periodontal treatment outcomes among teeth treated with non-surgical periodontal treatment, conventional flap surgery, or regenerative periodontal surgery. The study uses a multidimensional dataset including baseline clinical periodontal parameters, radiographic findings, documented treatment modalities, and patient-level demographic and clinical characteristics.
The analytical unit of the study is the tooth. Only periodontally involved teeth with complete baseline and follow-up clinical records, radiographic assessment, clearly documented treatment modality, and measurable periodontal outcomes are included in the predictive analyses. Full-mouth periodontal information is used for patient-level disease characterization, including periodontal staging and grading according to the 2017 AAP/EFP classification.
Because treatment allocation was not randomized, the models are intended to support treatment-specific outcome prediction and clinical interpretability rather than to establish causal superiority between treatment modalities.
Who can participate
Age range
16 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Patients with a confirmed diagnosis of periodontitis according to the 2017 AAP/EFP classification, supported by complete clinical and radiographic records.
. Availability of baseline clinical periodontal examination and radiographic records before periodontal treatment.
. Completion of active periodontal therapy, including non-surgical periodontal treatment and/or surgical periodontal treatment when clinically indicated.
. Availability of at least one post-treatment follow-up visit after completion of active periodontal therapy.
. Presence of at least one periodontally involved tooth meeting tooth-level eligibility criteria.
. Availability of detailed tooth-level documentation, including baseline periodontal measurements, radiographic assessment, documented treatment modality, and corresponding post-treatment outcome records.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Tooth-level Clinical Success of Periodontal Treatment
Timeframe: Baseline and final post-treatment follow-up after completion of active periodontal therapy; 12 to 48 months.
. Teeth were eligible for tooth-level analysis if they received one of the predefined periodontal treatment modalities: non-surgical periodontal treatment, conventional flap surgery, or regenerative periodontal surgery.
. Patients with a previous history of cancer were eligible if chemotherapy or radiotherapy had been completed and medical clearance for periodontal treatment had been obtained.
Exclusion criteria
. Incomplete demographic, clinical, radiographic, treatment, or follow-up records.
. Unclear or undocumented periodontal treatment modality.