Evaluation of Acid-base Disorders and Ventilation Settings in Cardiogenic Shock and Post-cardiac … (NCT07484828) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Evaluation of Acid-base Disorders and Ventilation Settings in Cardiogenic Shock and Post-cardiac Arrest Patients: Comparison With VentilO Algorithm
Canada100 participantsStarted 2026-05
Plain-language summary
This study aims to better understand how mechanical ventilation settings affect patients admitted to the coronary care unit after cardiac arrest or with cardiogenic shock. These patients often require mechanical ventilation, but current guidelines provide limited evidence on the best approach. Improper ventilation settings can lead to acid-base imbalances, such as respiratory acidosis or alkalosis, which may worsen patient outcomes.
The retrospective analysis will include 100 adult patients (50 post-cardiac arrest and 50 with cardiogenic shock) who were mechanically ventilated upon admission. The study has two main objectives:
Determine how often acid-base disorders occur in these patients and describe their characteristics.
Compare the initial ventilator settings chosen by clinicians with those suggested by VentilO, a decision-support algorithm.
The investigators will evaluate the potential effect of the VentilO recommendations on the first arterial (or capillary) blood gases compared to the real settings.
This information will help refine the algorithm and guide future research on improving ventilation strategies for critically ill cardiac patients.
Participation does not involve any intervention, as the study uses existing medical records.
Who can participate
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adult (Age \>=18 years old)
* Under mechanical ventilation with endotracheal tube for :
post cardiac arrest or cardiogenic shock
\- Bood gases result availability up to 4 hours after coronary unit admission
Exclusion Criteria:
* Lack of patient anthropometric data (height and weight) available in the patient record
* No information in the record regarding the data on the humidification systems used at the time of the first blood gas test upon admission to the coronary care unit.
* Patient stabilzed in other hospital before coronary unit admission or adjustment of respiratory parameters after a blood gas test.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial is comparing how doctors currently set ventilators against an algorithm called VentilO for patients in cardiogenic shock or after cardiac arrest — if I or my loved one were ever in that situation, could this kind of study affect the ventilator settings used during my care, and how would my team decide which approach to use?
2Since this trial is focused on detecting and comparing acid-base disorders like respiratory acidosis and alkalosis in critically ill patients, can you explain what those conditions mean for someone on a ventilator after cardiac arrest or in cardiogenic shock, and why getting those settings right matters so much?
3The trial isn't recruiting yet — does that mean there's currently no way to participate, and when it does open, what would actually be required of a patient or their family given that these patients are likely unconscious or in critical condition?
4Because this is listed as Phase NA and seems to be an observational or algorithmic comparison study rather than a drug trial, does that mean the main risk is in how ventilation is managed rather than a new medication, and how does that change the risk-benefit conversation I should have with you?
5Are there current standard-of-care approaches to managing ventilator settings in cardiogenic shock or post-cardiac arrest patients that my care team would use right now, and how does what this trial is testing compare to what I'd receive outside of it?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Acid-base disorder (respiratory acidosis)
Timeframe: Up to 4 hours after admission to the coronary care unit - First blood gas sample
2
Acid-base disorder (respiratory alcalosis)
Timeframe: Up to 4 hours after admission to the coronary care unit - First blood gas sample