Molecular Insights Into Post-Cardiac Arrest Brain Injury Via CSF Multi-Omics

Inclusion Criteria: * Patients receiving post-resuscitation care after out-of-hospital cardiac arrest for secondary brain injury treatment. * Patients without contraindications for lumbar puncture catheter insertion for cerebrospinal fluid (CSF) collection. This includes the absence of: * Uncontrolled diabetes.Coagulation disorders. * Thrombocytopenia (platelet count $\< 100,000). * A history of cirrhosis diagnosis. * Current receipt of low molecular weight heparin. * Current use of platelet inhibitors. * A history of posterior spinal fusion that may interfere with catheter insertion. * Local skin infection or rash at the puncture site. * Signs of systemic infection or sepsis. * A history of lumbar puncture within the past 6 hours. Exclusion Criteria: * Cerebral Edema: Patients with evidence of cerebral edema on a brain computed tomography (CT) scan performed immediately after spontaneous circulation recovery. * Patients who underwent extracorporeal membrane oxygenation (ECMO). * Patients who could not maintain integrated therapy for more than 24 hours after cardiac arrest. * Patients with a history of acute or chronic brain disease.