Serum Betatrophin Levels in Normal-Weight and Overweight Adolescents With PCOS

Inclusion Criteria: * Adolescent females aged 16-23 years * Post-menarche status * Diagnosis of polycystic ovary syndrome (PCOS) according to the Rotterdam criteria (for Groups I and II) * Age-matched healthy females without PCOS for control group (Group III). * Ability and willingness to provide informed consent/assent * Willingness to comply with study procedures and blood sample collection Exclusion Criteria: * Cardiovascular diseases including hypertension * Type 1 or type 2 diabetes mellitus * Morbid obesity * Primary adrenal insufficiency * Uterine fibroids * Thyroid dysfunctions including Hashimoto thyroiditis and Grave's disease * Hepatic dysfunctions * Renal insufficiency * Genetic disorders in chromosome constitution or karyotype analysis including monosomy X, trisomy X and gene mutations as BMP15, FMR I, POFIB, and GDF9 * Neurologic diseases * Psychiatric disorders * Autoimmune diseases or syndromes including Addison's disease, autoimmune syndromes, scleroderma, Sjogren's syndrome, myasthenia gravis, inflammatory bowel diseases, multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus and familial Mediterranean fever * History of any malignancy * History of exposure to chemotherapeutic agents or radiotherapy