CompletedNot Applicable

Brain and Gene Expression Responses to Exercise in Chronic Back Pain

Canada57 participantsStarted 2017-03-31

Plain-language summary

This study is registered retrospectively for transparency. This mechanistic randomized controlled trial examined whether a 14-week supervised physical exercise training program reduces chronic low back pain (CLBP) by modulating frontostriatal brain connectivity and immune-related gene expression. Fifty-seven adults with CLBP were randomized to exercise training or wait-list control. Participants underwent pre- and post-intervention MRI, questionnaires, and blood sampling. The study tested whether reductions in nucleus accumbens-medial prefrontal cortex connectivity and changes in inflammatory gene expression mediated exercise-induced pain relief.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age ≥ 18 years * Chronic low back pain ≥ 3 months * Pain present at least half the days over the past 6 months * Average pain intensity ≥ 3/10 during week prior to enrollment Exclusion Criteria: * Diabetes * Neurological disorder * Psychiatric disorder * Significant cardiorespiratory disease * Under 18 years of age

What they're measuring

Chronic Low Back Pain Intensity

Timeframe: Assessed at Baseline (Pre-intervention, Week 0) and Post-intervention (Week 14)

Trial details

NCT IDNCT07480460

SponsorMcGill University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2021-12-14

View on ClinicalTrials.gov More Chronic Low Back Pain (CLBP) trials