Periodontal Status and Cytokine Levels in Patients With Non-Infectious Uveitis (NCT07480291) | Clinical Trial Compass
CompletedNot Applicable
Periodontal Status and Cytokine Levels in Patients With Non-Infectious Uveitis
Turkey (Türkiye)52 participantsStarted 2020-10-01
Plain-language summary
This cross-sectional observational study aimed to evaluate periodontal clinical parameters and inflammatory cytokine levels in gingival crevicular fluid (GCF), saliva, and serum in patients with non-infectious uveitis (NIU) compared with systemically healthy individuals.
Twenty-five patients diagnosed with non-infectious uveitis and twenty-seven age- and sex-matched healthy controls were included. Clinical periodontal parameters including probing pocket depth, clinical attachment loss, plaque index, gingival index, and bleeding on probing were recorded. Biological samples including saliva, gingival crevicular fluid, and serum were collected.
Levels of TNF-α, IL-1β, IL-2, IL-6, IL-8, IL-10, and IL-17 were measured using ELISA. The study aimed to investigate whether periodontal inflammatory status and systemic cytokine profiles are associated with non-infectious uveitis.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Participants aged 18 years or older.
* Patients diagnosed with non-infectious uveitis according to the
* Standardization of Uveitis Nomenclature (SUN) criteria.
* Presence of at least 20 natural teeth.
* Individuals who agreed to participate in the study and provided informed consent.
Exclusion Criteria:
* Presence of infectious uveitis.
* Pregnancy or lactation.
* Use of antibiotics, anti-inflammatory drugs, or immunosuppressive therapy within the previous 6 months.
* History of periodontal treatment within the previous 6 months.
* Presence of systemic diseases known to affect periodontal status.
* Current smokers.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This study looked at the connection between gum disease and non-infectious uveitis by measuring a specific immune marker called IL-10 in the blood — has my doctor seen the results, and do they change anything about how my uveitis or gum health should be monitored?
2Since this was an observational study measuring cytokine levels rather than testing a treatment, does the data suggest that getting my periodontal disease treated could actually affect my uveitis, or is the relationship still unclear?
3The trial is now completed — is there published data my doctor can review, and if so, does anything in the findings suggest I should be seeing a periodontist as part of managing my uveitis?
4Given that this study focused on IL-10, an immune signaling molecule, does my doctor think checking my own inflammatory markers could help guide my uveitis treatment plan?
5Are there follow-up trials or treatment studies building on this research that my doctor thinks might be worth looking into, given that this one was observational and didn't test a specific intervention?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.