Obesity and Aging: Impacts of Nutritional Counseling and Physical Exercise on Telomeres and Senes… (NCT07479940) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Obesity and Aging: Impacts of Nutritional Counseling and Physical Exercise on Telomeres and Senescence Parameters
Brazil60 participantsStarted 2026-03-01
Plain-language summary
The study will involve 80 elderly women, 40 eutrophic and 40 obese, divided into four groups, each with n=20. 1) Eutrophic Group (EG) undergoing only nutritional counseling (NC), 2) Eutrophic Group with NC and combined training (CT), 3) Obese Group (OG) undergoing only NC, and 4) Obese Group with NC and CT. The study will be divided into two main phases: an initial 9-week phase dedicated to NC, followed by a 20-week CT phase.
Who can participate
Age range
60 Years – 75 Years
Sex
FEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria
* being female;
* between 60 and 75 years old;
* a BMI between 22 and 40 kg/m²;
* being sedentary (not exercising for at least 3 months).
Exclusion Criteria:
* a history of cancer, autoimmune or neurodegenerative diseases;
* excessive alcohol consumption;
* smoking
* score ≤13 on the Mini-Mental State Examination (MMSE).
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Telomere length in peripheral blood mononuclear cells (PBMCs) measured by quantitative PCR
Timeframe: 9 and 29 weeks
2
Expression of cellular senescence-related genes in PBMCs measured by quantitative RT-PCR
Timeframe: 9 and 29 weeks
3
Adequacy of protein intake assessed by dietary intake analysis
Timeframe: 0, 9 and 29 weeks
4
Percentage of ultra-processed food consumption assessed by NOVA food classification
Timeframe: 0, 9 and 29 weeks
5
Diet quality assessed by proportion of ultra-processed food consumption according to the NOVA classification