A Comparative Phase 1 Study to Evaluate the Pharmacokinetic and Safety of QL2106 vs Tremfye® in Healthy Subjects

Inclusion Criteria: * Healthy subjects aged from 18 to 45 years (including the boundary value)； * BMI between 19-26 kg/m2 (including boundary value) and body weight between 50-90 kg (including boundary value); * Normal results of physical examination/laboratory examination/ECG or abnormal with no clinical significance according to the PI's judgment; * The subject (including partner) has no pregnancy plan or sperm donation plan during the whole trial period and within 3 months after the completion of the drug administration and voluntarily adopts effective contraceptive measures; * Sign the informed consent before joining the study, and fully understand the content, process and possible risks. Exclusion Criteria: * History of allergic reactions or hypersensitivity to Guselkumab, other IL-23 biologics or excipients; * Alcoholics，or subjects who consumed more than 14 units of alcohol per week in the 6 months before screening; * Those who had lost blood or donated at least 400 mL in the 3 months prior to screening, or had lost blood or donated at least 200 mL in the 1 month prior to screening, or planned to donate blood during the trial； * Those who smoked more than 5 cigarettes per day in the 3 months before screening; * Drug users in the 5 years prior to screening, or positive urine drug screening； * Having used Guselkumab (or its biosimilars) or interleukin (IL-23) targeting agents; * Those who have been enrolled in other clinical studies or less than 3 months since the end…