Brief Title: Aerobic Training on Cerebrovascular Function, Cognition and Gait in Parkinson's Disease (NCT07478146) | Clinical Trial Compass
RecruitingNot Applicable
Brief Title: Aerobic Training on Cerebrovascular Function, Cognition and Gait in Parkinson's Disease
Brazil40 participantsStarted 2026-02-28
Plain-language summary
This randomized controlled trial will investigate the effects of a 12-week supervised aerobic training program on cerebrovascular function, peripheral vascular health, cardiovascular autonomic modulation, cognition, non-motor symptoms, sleep, mood, gait biomechanics, quality of life, and body composition in patients with Parkinson's disease (Hoehn \& Yahr stages 1-3). Participants will be randomly allocated to aerobic training or usual care.
Who can participate
Age range
40 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Clinical diagnosis of Parkinson's disease
* Hoehn \& Yahr stages 1-3
* Stable antiparkinsonian medication for at least 4 weeks
* Montreal Cognitive Assessment (MoCA) score ≥ 18
* Ability to walk independently (with or without assistive device)
* Medical clearance for participation in moderate-intensity exercise
Exclusion Criteria:
* Change in medication
* Contraindication to exercise
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in Cerebrovascular Reactivity
Timeframe: Baseline and 12 weeks
2
Change in Neurovascular Coupling at 12 Weeks.
Timeframe: Baseline and 12 weeks
3
Change in Dynamic Cerebral Autoregulation
Timeframe: Baseline and 12 weeks
4
Change in Acute Cerebral Blood Flow Response to Exercise