RecruitingNot Applicable

Brief Title: Aerobic Training on Cerebrovascular Function, Cognition and Gait in Parkinson's Disease

Brazil40 participantsStarted 2026-02-28

Plain-language summary

This randomized controlled trial will investigate the effects of a 12-week supervised aerobic training program on cerebrovascular function, peripheral vascular health, cardiovascular autonomic modulation, cognition, non-motor symptoms, sleep, mood, gait biomechanics, quality of life, and body composition in patients with Parkinson's disease (Hoehn \& Yahr stages 1-3). Participants will be randomly allocated to aerobic training or usual care.

Who can participate

Age range40 Years

SexALL

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Inclusion Criteria: * Clinical diagnosis of Parkinson's disease * Hoehn \& Yahr stages 1-3 * Stable antiparkinsonian medication for at least 4 weeks * Montreal Cognitive Assessment (MoCA) score ≥ 18 * Ability to walk independently (with or without assistive device) * Medical clearance for participation in moderate-intensity exercise Exclusion Criteria: * Change in medication * Contraindication to exercise

What they're measuring

Change in Cerebrovascular Reactivity

Timeframe: Baseline and 12 weeks

Change in Neurovascular Coupling at 12 Weeks.

Timeframe: Baseline and 12 weeks

Change in Dynamic Cerebral Autoregulation

Timeframe: Baseline and 12 weeks

Change in Acute Cerebral Blood Flow Response to Exercise

Timeframe: Baseline and 12 weeks

Trial details

NCT IDNCT07478146

SponsorRaphael Mendes Ritti Dias

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-06-30

Contact for this trial

Raphael M Ritti-Dias, PhD

+5519999406878 raphaelritti@gmail.com

View on ClinicalTrials.gov More PARKINSON DISEASE (Disorder) trials