A Study to See How Safe and Effective Alirocumab is When Given Weekly to Adult Participants Who H… (NCT07477704) | Clinical Trial Compass
RecruitingPhase 2
A Study to See How Safe and Effective Alirocumab is When Given Weekly to Adult Participants Who Have Hypercholesterolemia
United States420 participantsStarted 2026-06-17
Plain-language summary
This study is researching an experimental drug called alirocumab, referred to as "study drug". In the United States, alirocumab is approved for the treatment of hypercholesterolemia (high blood cholesterol levels).
The aim of the study is to see how safe and effective alirocumab is when given weekly to adult participants who have hypercholesterolemia.
The study is looking at several other research questions, including:
* What side effects may happen from taking the study drug once a week
* How much study drug is in the blood at different times
Who can participate
Age range
18 Years – 80 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Exclusion criteria
. Participant plans to initiate or change dose of lipid-lowering therapy
. Use of any PCSK9 inhibitors
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Since this is a Phase 2 trial of alirocumab given weekly, what does that phase mean for how much is known so far about its safety and effectiveness compared to the already-approved every-two-week version?
2This trial is specifically measuring percent change in LDL cholesterol — based on my current LDL levels and treatment history, is that the right goal for where I am in managing my hypercholesterolemia?
3Alirocumab is being tested as a weekly injection here, whereas existing approved doses are given every two weeks — how would committing to a weekly injection schedule realistically fit into my life, and is that something worth discussing before I consider enrolling?
4Are there standard treatments or already-approved cholesterol-lowering medications I should try first before considering a Phase 2 trial like this one?
5Since this trial is actively recruiting, what would the screening and enrollment process look like, and are there any eligibility requirements based on my specific cholesterol levels or medical history that my doctor should review first?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.