Teenthrive 2: Treatments for Improving Mood in Teens (NCT07475845) | Clinical Trial Compass
RecruitingNot Applicable
Teenthrive 2: Treatments for Improving Mood in Teens
United States96 participantsStarted 2026-06-15
Plain-language summary
In this study, we will conduct a pilot RCT of a yoga-based intervention (YBI) vs. group cognitive-behavioral therapy (gCBT) at two sites. We will recruit 48 adolescent participants each in Columbus, OH and Boston, MA (96 total). We have a priori targets for indices of feasibility and acceptability, including recruitment rate, retention for assessments, class attendance, interventionist fidelity to manuals, and participant satisfaction. We hypothesize that we will meet these metrics at both sites.
Who can participate
Age range
12 Years – 18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Have elevated depressive symptoms, defined by: a) a score of 1 or greater on the PHQ-2 and 5 or greater on the PHQ-8 at screening; and b) a score of 10 or higher on the Quick Inventory of Depression-Adolescent Version-Clinician Rating (QIDS-A-CR), including either sad mood or anhedonia;
. Be aged 12-18;
. Be allowed to participate in gym class or sports at school (or, if not, medically cleared by their primary care provider or other relevant healthcare provider);
. Be able to read and write in English;
. Provide consent/assent appropriate to age;
. Be able to attend group session times:
. Have access to a private space once per week that is suitable for synchronous intervention sessions.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial seems to be measuring things like how credible teens find the program and how satisfied they are with it, rather than directly measuring whether depression symptoms improve — can you help me understand what that means for whether it might actually help my teen's mood?
2Since this study is listed as Phase NA, which often means it's testing a program or approach rather than a medication, can you explain what kind of treatment or intervention my teen would actually be doing, and how demanding the schedule would be week to week?
3The trial tracks class attendance as one of its main outcomes — how many sessions would my teen need to attend, and is there a concern that missing classes could affect what they get out of it?
4Given that this is still in a research phase focused on program satisfaction and engagement rather than proven clinical outcomes, would you recommend this trial over starting with an established therapy like CBT or medication right away?
5How would my teen's progress be monitored for safety during this study, especially if their depression symptoms get worse while they're participating?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
. Meet criteria for lifetime bipolar I disorder, a current psychotic disorder, or current anorexia or bulimia; or currently be in treatment for anorexia or bulimia;
. Meet criteria for substance use disorder (SUD) in the previous 12 months, with current symptoms of sufficient severity to interfere with study participation;
. Have severe depression (QIDS-A-CR score \> = 16);
. Have moderate or high risk for suicide (Response of "yes" on CSSRS-Screener item 3,4,5,6 with regard to the past 3 months).
. Have suicide ideation (Response of "yes" on CSSRS- Screener item 2) and do not currently have other mental health treatment (pharmacotherapy or psychotherapy)
. Are pregnant;
. Are currently (past 4 weeks) engaged in yoga classes or in gCBT;
. Have had substantive changes in other psychiatric treatment in the previous 4 weeks (e.g., started a new depression medication; stopped or started attending psychotherapy).