Understanding the Impact of Meal Timing on Neurological Health in Adults With Multiple Sclerosis (NCT07475377) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Understanding the Impact of Meal Timing on Neurological Health in Adults With Multiple Sclerosis
United States22 participantsStarted 2026-07-01
Plain-language summary
The goal of this clinical trial is to learn if the time an individual eats each day impacts neurological health in people with multiple sclerosis. The main questions the investigators are asking are:
1. Does meal timing affect biomarkers of neuronal health (neurofilament light chain \[NfL\] and BDNF) and inflammation (IL-6, IL-17, TNF-ɑ) in adults with MS.
2. Does meal timing affect expression of circadian clock genes and genes associated with autophagy in adults with MS.
Participants will be instructed to start and stop eating at specific times each day based on their group assignment and their personal schedule. They will respond to prompts sent to them on their smartphone to record the times they start and stop eating each day.
As a secondary goal, the study will also explore the feasibility of including translocator protein (TSPO)-PET imaging of neuroinflammation in future clinical trials of TRE in people with MS. To accomplish this, imaging will be completed in a subset of 8 participants at the beginning and end of the study.
Who can participate
Age range
18 Years – 64 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Diagnosed with relapsing remitting or secondary progressive multiple sclerosis (RRMS or SPMS)
* If on disease modifying therapy (DMTs), stable for 6 months
* If not on DMTs, no DMT usage within previous 6 months
* BMI 18.5-50 kg/m2
* Access to a smartphone
* Responsible for personal eating schedule or able to have input into schedule
Exclusion Criteria:
* Relapse within previous 30 days
* Actively engaged in a weight loss program or unwilling to follow assigned eating schedule
* Current use of GLP-1 or use within previous 3 months
* Regularly fasts \> 12 hours/day
* Employed in night shift or rotating shift work
* Unable to walk 25 feet with or without assistive device (EDSS \> 6.5).
* Current use of insulin or sulfonylurea agents
* Pregnant or breastfeeding
* Currently enrolled in another trial that would confound results (e.g., exercise studies or other diet studies)
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.