CompletedPhase 4

The Effect of Dexmedetomidine Infusion Alone Versus the Combination of Dexmedetomidine and Melatonin on Reduction of Post-operative Delirium (POD) After Open Brain Surgeries

Egypt100 participantsStarted 2025-08-01

Plain-language summary

The aim of this study is to illuminate the effect of combination of dexmedetomidine and oral melatonin versus the use of dexmedetomidine infusion alone on the improving of post-operative delirium (POD) on patients undergoing open brain surgeries.

Who can participate

Age range30 Years – 60 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age: 30 - 60 years * Sex: Both sexes * Patients with open space occupying lesions or hematoma. Exclusion Criteria: * Refusal of the patient to give written informed consent. * History of allergy to the medications used in the study. * Psychiatric disorder. * Any form of drug addiction. * Patients receiving any anti-psychotic medications. * History of previous brain insult (Ischemic or haemorrhagic infarctions). * Pre-operative dementia. * History of malignant hyperthermia * Patient's suffering from bradycardia * Patient's suffering from hypotension

What they're measuring

The incidence of POD

Timeframe: Perioperatively

Trial details

NCT IDNCT07475156

SponsorAin Shams University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-01-15

View on ClinicalTrials.gov More Post Operative Delerium trials