Serious Game Rehabilitation and Brain Plasticity in MS (NCT07474129) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Serious Game Rehabilitation and Brain Plasticity in MS
40 participantsStarted 2026-06
Plain-language summary
This prospective, interventional, longitudinal, multicentre study aims to evaluate the impact of the "Serious game", an innovative cognitive remediation tool on brain reorganization in Multiple sclerosis patients, using functional Magnetic resonance imaging (MRI). The serious game is a tool combining the motivational mechanisms of video games with cognitive remediation techniques.
Who can participate
Age range
18 Years – 65 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* People with relapsing-remitting or progressive MS defined according to the 2010 revised McDonald criteria \[56\]
* Cognitive complaints and deficits in at least one score on the initial neuropsychological examination (\<5th percentile of the reference group)
* Aged between ≥ 18 and ≤ 65 years
* No defined relapse for at least 6 weeks
* At least 4 weeks since a corticosteroid bolus
* Patient with an internet connection
* Patient covered by social security
* Signed informed consent
Exclusion Criteria:
* Claustrophobia preventing MRI;
* Contraindication to MRI;
* Wearing fixed dental braces;
* Unable to receive oral and written information;
* Unable to use the software (due in particular to motor and/or sensory difficulties);
* Neurological or psychiatric comorbidity, other than MS and anxiety-depression syndrome,
* Patient with severe anxiety-depression syndrome (BDI-FS \> 10),
* Pregnant or breastfeeding women
* Taking neuroleptic treatment
* Person under guardianship or curatorship
* Person deprived of liberty
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Mean activation of the brain region involved in the functional network