RecruitingNot Applicable

Multimodal Clinical Study of Electroconvulsive Therapy and Magnetic Seizure Therapy

China200 participantsStarted 2025-09-01

Plain-language summary

To compare the efficacy and tolerability of Electroconvulsive Therapy (ECT) and Magnetic Seizure Therapy (MST) in patients with major depressive disorder (MDD).

Who can participate

Age range12 Years – 80 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Patients Inclusion Criteria: Aged 12-80 years; Diagnosis confirmed by two psychiatrists per DSM-5; Stable medication regimen pre-enrollment; Indicated for neuromodulation OR with visual field defects. Patients Exclusion Criteria: Major systemic diseases; Prior neuromodulation within 3 months; Pregnancy or potential pregnancy; Metal implants or claustrophobia. Healthy Control Inclusion Criteria: Aged 12-80 years; No history of neuropsychiatric disorders; No significant systemic diseases; Normal or corrected vision. Healthy Control Exclusion Criteria: Metal implants or claustrophobia; Ocular diseases or surgery history.

What they're measuring

Change in Hamilton Depression Rating Scale Total Score.

Timeframe: Baseline, immediately after each treatment session during the intervention period, and 6 months after the end of intervention.

Change in heart rate variability (HRV) parameters derived from electrocardiogram (ECG).

Timeframe: Baseline, immediately after each treatment session during the intervention period, and 6 months after the end of intervention.

Change in Hamilton Anxiety Rating Scale Total Score.

Timeframe: Baseline, immediately after each treatment session during the intervention period, and 6 months after the end of intervention.

Change in the Overall Composite Score of the MATRICS Consensus Cognitive Battery.

Timeframe: Baseline and after the completion of the last session (an average of 2 weeks).

Trial details

NCT IDNCT07473648

SponsorThe Second Hospital of Anhui Medical University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-12

Contact for this trial

Yanghua Tian PhD

0551 6599 7278 zylykd@163.com

View on ClinicalTrials.gov More Electroconvulsive Therapy trials

Who can participate

Age range12 Years – 80 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Change in Hamilton Depression Rating Scale Total Score.

Timeframe: Baseline, immediately after each treatment session during the intervention period, and 6 months after the end of intervention.

Change in heart rate variability (HRV) parameters derived from electrocardiogram (ECG).

Timeframe: Baseline, immediately after each treatment session during the intervention period, and 6 months after the end of intervention.

Change in Hamilton Anxiety Rating Scale Total Score.

Timeframe: Baseline, immediately after each treatment session during the intervention period, and 6 months after the end of intervention.

Change in the Overall Composite Score of the MATRICS Consensus Cognitive Battery.

Timeframe: Baseline and after the completion of the last session (an average of 2 weeks).