Pesticides and Infertility: Oxidative Stress Via Circulating Cell-free DNA and Gut/Genital Microbiome Signatures in Women With Endometriosis

Inclusion Criteria: * The "case" group will include: * All women aged 18 to 43, with confirmed endometriosis and endometriosis grade 3 or 4 as defined by the 1985 revised version of the American Society of Reproductive Medicine. * The "control" group will include: * All women aged between 18 and 43, whose infertility problem is proven male infertility and who do not have endometriosis identified by biological, genetic and clinical tests. * The following criteria will apply to both groups: * All women who have not received antibiotic treatment in the three months preceding inclusion and who are not participating in any pharmacological study. * All women who are covered under the national social security health insurance scheme. * All women who have signed a written informed consent form, thereby confirming their participation in the study after a period of free and informed reflection. Exclusion Criteria: * All women aged 44 and over. * Women who are overweight, obese or anorexic. * Women taking antibiotics 3 months prior to inclusion, or participating in a drug study. * All women under anti-GnRH treatment, pregnant or suffering from a chronic inflammatory disease such as Crohn's disease, polycystic ovary syndrome, etc. * All women whose endometriosis has not been formally confirmed by the tests offered by the Reproductive Medicine and Biology Department, CECOS de Picardie, CHU Amiens-Picardie. * All patients under guardianship, curators or safeguard of justice. * All patie…