Effects of an Aerobic Exercise Program on Cardiovascular Risk in Patients With Chronic Kidney Dis… (NCT07469540) | Clinical Trial Compass
RecruitingNot Applicable
Effects of an Aerobic Exercise Program on Cardiovascular Risk in Patients With Chronic Kidney Disease or Rheumatoid Arthritis
France90 participantsStarted 2026-03-16
Plain-language summary
The goal of this clinical trial is to determine whether an aerobic exercise program can reduce cardiovascular risk in patients with systemic inflammation, such as those with rheumatoid arthritis and chronic kidney disease.
The main questions this study aims to address are:
* Does an individualized aerobic exercise program reduce cardiovascular risk, as assessed arterial stiffness and endothelial function ?
* What are the effects of this exercise program on inflammation and immunosenescence?
Researchers will compare an individualized aerobic exercise program with a therapeutic education program (consisting of educational phone calls only) and a control group with no intervention.
Participants will:
* Perform three physical activity sessions per week for six weeks (45-minute sessions at 60-80% of heart rate reserve);
* Attend clinic visits at baseline, after the 6-week intervention, and at a 6-week follow-up after the intervention;
* Undergo assessments including pulse wave velocity, hyperemic reactivity, and blood analyses.
Who can participate
Age range
50 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Diagnosis of Chronic Kidney Disease (CKD) or Rheumatoid Arthritis (RA), with no other risk factors related to the disease.
* Having a glomerular filtration rate between 45 and 20 ml/min/1.73 m², corresponding to stages III and IV not on dialysis for patients with CKD ; or have a DAS 28 score ≥ 2.6 points for patients with RA.
* Have a medical certificate stating that there are no adverse reactions to physical activity.
* Affiliation with a French social security scheme or beneficiary of such a scheme.
Exclusion Criteria:
* Unstabilised corticosteroid therapy and/or \>10mg prednisone/day
* Uncontrolled high blood pressure
* Pregnant women
* Impaired higher functions making it impossible to understand and adhere to an aerobic exercise program
* Inability to perform physical exercise, regardless of the cause (neurological, central or peripheral, cardiovascular or respiratory, or musculoskeletal)
* Legal incapacity or limited legal capacity
* Subject unlikely to cooperate with the study and/or low cooperation anticipated by the investigator
* Subject without health insurance
* Subject is in the exclusion period of another study involving human subjects that may interfere with the results of this study, particularly by affecting inflammatory status and the cardiovascular system.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Arterial stiffness
Timeframe: From baseline to 12-weeks follow-up (three time points).