Serum Inflammatory Protein Concentration During Dental Treatment (NCT07468929) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Serum Inflammatory Protein Concentration During Dental Treatment
United States30 participantsStarted 2026-05
Plain-language summary
The goal of this observational study is to study the molecular markers of stress in blood samples from people who are having periodontal surgery. The main question it aims to answer are:
* How do the levels of inflammatory molecules in the blood change during a periodontal surgery?
* How are the levels of inflammatory molecules in a person having surgery different from the levels in a person having a nonsurgical procedure?
* Participants will be people who are having a periodontal surgery or a nonsurgical periodontal treatment as part of their dental care. Participants will be asked to let the investigator take blood samples from them before, during, and after the procedure is being done. The blood will later be analyzed for substances in the blood that are associated with inflammation.
Who can participate
Age range
21 Years – 75 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adults 21-75 years of age
* Systemically healthy
* Non-smoker
* scheduled to receive nonsurgical or surgical periodontal treatment under IV sedation
Exclusion Criteria:
* Patients who have localized form of the disease (less than 30% of available tooth/implant sites are affected with the disease)
* Non-english speaking individuals since informed consent form will be in English only.
* Patients with uncontrolled systemic diseases (such as metabolic diseases, obesity, diabetes, high blood pressure) since these types of chronic inflammatory challenges would cause increase levels of circulatory serum pro-inflammatory markers.
* Pregnant patients (pregnancy will be reported by the patient) since pregnancy itself would affect circulatory serum pro-inflammatory markers.
* Patients who are not willing to have blood drawing for the study purpose.
* Patients who are not willing to sign research related consent form.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Serum CRP concentration (pg/ml)
Timeframe: Immediately prior to procedure; approximately midway through the procedure; immediately after procedure ends;
2
Seum IL-1 concentration (pg/ml)
Timeframe: During dental procedure intervention
3
Serum TNF concentration (pg/ml)
Timeframe: Blood samples will be obtained immediately before, during and immediately after dental procedure intervention.