Repeat Treatment With Metered Cryospray in Patients With Chronic Obstructive Pulmonary Disease With Chronic Bronchitis

Inclusion criteria

• . Subject has completed a previous MCS study, including both treatments (treatment day 1 and treatment day 2)
• . Males and females \<80 years of age
• . Subject is able to read, understand, and sign a written informed consent form in order to participate in the study
• . Subject has a diagnosis of chronic obstructive pulmonary disease (COPD) with chronic bronchitis (CB) for a minimum of two years. (CB is defined clinically as chronic productive cough for 3 months in each of 2 successive years in a patient in whom other causes of productive cough have been excluded)
• . Subject is classified as having a moderate or severe (GOLD 2/3) airflow obstruction defined by a post-bronchodilator of \>30% FEV1 to \<80% predicted with a baseline FEV1/FVC of \<0.70
• . Subject is being treated according to current medically accepted treatment guidelines for CB for minimum of 3 months prior to enrollment into the study.
• . Non-smoking for a minimum of 2 months prior to consent and agrees to continue not smoking for the duration of the study
• . Subject is able to adhere to and undergo 2 bronchoscopic procedures per hospital guidelines

Exclusion criteria