Not Yet RecruitingNot Applicable

SENS'REM - SENSoriality and Multi-Sensory Emotional Reminiscences: a Pilot Study

France10 participantsStarted 2026-09

Plain-language summary

SENS'REM is a pilot feasibility study evaluating a new non-drug therapeutic program based on multisensory reminiscence using immersive virtual reality in older adults living in nursing homes or long-term care units who present cognitive impairment and apathy. Apathy is a frequent symptom in people with neurocognitive disorders. It is characterized by a loss of motivation, reduced interest in activities, and decreased emotional engagement. Apathy strongly affects quality of life, social interactions, and participation in care, and current drug treatments have limited effectiveness. For this reason, non-pharmacological approaches are increasingly recommended. The SENS'REM program combines virtual reality with personalized multisensory stimulation (visual, auditory, olfactory and gustatory) to help participants relive meaningful autobiographical memories in an immersive and emotionally engaging environment. Each participant receives one session per week for six weeks. The content of the sessions is adapted to the individual life history of each participant. The primary objective of this study is to evaluate the feasibility of implementing this program in institutional settings, including recruitment, organization, technical aspects, and participant adherence. Secondary objectives include evaluating changes in apathy, quality of life, cognitive functioning, social engagement, participant satisfaction, and the tolerance of the intervention. The main hypothesis of the study is that a personalized multisensory virtual reality reminiscence program is feasible in nursing home and long-term care settings and may contribute to a reduction in apathy and an improvement in engagement and well-being among older adults with cognitive impairment. This pilot study will provide essential preliminary data to optimize the intervention and prepare a future larger comparative clinical trial.

Who can participate

Age range

65 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Men or women aged 70 years or older * Living in a nursing home (EHPAD) or long-term care unit (USLD) for at least 3 months * Sufficient French language ability to understand the study procedures * Presence of apathy confirmed by a positive score on the Apathy Inventory * Moderate cognitive impairment documented by a Montreal Cognitive Assessment (MoCA) score between 10 and 17 * Affiliated with a social security or health insurance system * Medical approval for virtual reality exposure (no contraindication) * Ability to provide informed consent, or consent provided by a legal representative or trusted person when applicable Exclusion Criteria: * "Diagnosed psychiatric disorder according to DSM-5 criteria (e.g., schizophrenia, bipolar disorder) * Severe or acute behavioral disturbances incompatible with study participation * Neurological comorbidities incompatible with virtual reality use (e.g., Lewy body disease, history of epilepsy) * Severe sensory impairment (vision, hearing, or olfaction) preventing participation * Known susceptibility to cybersickness based on the CyberSickness in Virtual Reality Questionnaire (CSQ-VR) * Presence of a cardiac pacemaker incompatible with virtual reality headset use * Withdrawal of informed consent at any time during the study"

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Overall feasibility of the multisensory virtual reality reminiscence intervention in institutional settings

Timeframe: at 12 months

Trial details

NCT IDNCT07468305

SponsorCentre Hospitalier Universitaire de Nice

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-02

Contact for this trial

Anne-Julie Vaillant-Ciszewicz, PhD

+33615938590 vaillant-ciszewicz.aj@chu-nice.fr

View on ClinicalTrials.gov More Apathy trials