The EnvScore-Aorte Diagnostic Study Protocol for the Identification of Acute Aortic Syndrome (NCT07467486) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
The EnvScore-Aorte Diagnostic Study Protocol for the Identification of Acute Aortic Syndrome
580 participantsStarted 2026-04
Plain-language summary
The goal of this retrospective observational study is to evaluate the diagnostic performance of the AORTAs score integrated with environmental exposure data (AORTAs-E) for the identification of Acute Aortic Syndrome (AAS) during initial maangement in the emergency departement.
The main question it aims to answer is:
Can the integration of real-time meteorological and atmospheric pollution data improve the early identification of AAS in patients presenting in the emergency department for chest, abdominal, or back pain?
Researchers will analyze medical records and environmental data for 580 adult patients (290 cases with confirmed AAS and 290 controls) managed at the University Hospital of Besançon between 2014 and 2026. Environmental exposure, including temperature and pollutant concentrations, will be calculated based on each patient's residential address to determine if adding these factors to clinical data increases diagnostic accuracy.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria (Cases - AAS+) :
* Adults (\>18 years)
* Diagnosis of AAS (aortic dissection, intramural hematoma, or penetrating atherosclerotic ulcer) identified according to medicalization programs for information systems
* Diagnosis confirmed by imaging (CTA, TTE, or TOE)
Inclusion Criteria (Controls - AAS-):
* Adults (\>18 years)
* Presenting in the emergency department for chest, back, or abdominal pain.-
* Confirmed differential diagnosis by CTA, ruling out AAS
Exclusion Criteria:
* Post-traumatic or iatrogenic AAS.
* Subacute (8-30 days) or chronic symptoms (\>30 days).
* Patients under legal protection or unable to provide consent/non-opposition.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Area Under the Receiver Operating Characteristic (ROC) Curve (AUC) of the AORTAs scores.
Timeframe: From January 2014 to January 2026
Trial details
NCT IDNCT07467486
SponsorCentre Hospitalier Universitaire de Besancon