Low-FODMAP Diet and Intestinal Permeability in Patients With Irritable Bowel Syndrome

Inclusion Criteria:Age between 18 and 65 years Diagnosis of Irritable Bowel Syndrome (IBS) according to Rome IV criteria Patients presenting to Internal Medicine or Gastroenterology outpatient clinics Ability to provide written informed consent Willingness to comply with the assigned dietary intervention and follow-up schedule Patients who were mostly compliant or fully compliant with the dietary protocol (≥51%) \- Exclusion Criteria: * IBS-specific treatment within the last 1 month Antibiotic or probiotic use within the previous 2 weeks History of major abdominal surgery Active malignancy Heart failure Renal failure Autoimmune disease Inflammatory bowel disease Celiac disease Lactose intolerance Individuals currently following another dietary regimen Pregnancy Poor adherence to diet protocol (\<51%) Failure to submit dietary diaries regularly Need for antibiotic therapy during the intervention period