Effects of Minimal and Metabolic Flow Sevoflurane Anesthesia in Gynecological Surgery Patients (NCT07465146) | Clinical Trial Compass
CompletedNot Applicable
Effects of Minimal and Metabolic Flow Sevoflurane Anesthesia in Gynecological Surgery Patients
Turkey (Türkiye)97 participantsStarted 2024-11-05
Plain-language summary
The aim of this study is to observe the effects of minimal and metabolically required basal anesthetic gas flow rates delivered by the anesthesia workstation under general anesthesia on body temperature, blood pressure, and heart rate during surgery.
It also aims to evaluate the impact of reducing excessive delivery of anesthetic gases, air, and oxygen beyond the patient's physiological needs during general anesthesia on minimizing the harmful effects of anesthetic gases on the environment, climate, and global warming, as well as on contributing positively to hospital costs.
Who can participate
Age range
18 Years – 65 Years
Sex
FEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Female patients aged 18-65 years
* Undergoing elective gynecologic surgery under general anesthesia (including hysterectomy and/or oophorectomy)
Exclusion Criteria:
* Pregnant patients
* Patients with advanced cardiac disease
* Patients with advanced renal disease
* Patients with advanced hepatic disease
* Patients with advanced respiratory disease
* Severe obesity
* Heavy smokers
* Excessive alcohol consumption
* Known allergic sensitivity to halogenated anesthetic gases
* Use of medications that may interact with volatile anesthetics
* History of or susceptibility to malignant hyperthermia or neuromuscular disorders
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Core body temperature (°C)
Timeframe: From induction of anesthesia until the end of surgery (approximately 1-2 hours)
2
Mean intraoperative heart rate (bpm)
Timeframe: From induction of anesthesia until the end of surgery (approximately 1-2 hours)
3
Mean intraoperative mean arterial pressure (mmHg)
Timeframe: From induction of anesthesia until the end of surgery (approximately 1-2 hours)
4
Anesthetic gas consumption (mL)
Timeframe: From induction of anesthesia until the end of surgery (approximately 1-2 hours)
5
Richmond Agitation-Sedation Scale (RASS) (-5 to 4)
Timeframe: At the end of surgery / immediate postoperative period