Prefrontal Glutamatergic Modulation by NAC and MBCT for Depression in Youth (NCT07464886) | Clinical Trial Compass
RecruitingPhase 3
Prefrontal Glutamatergic Modulation by NAC and MBCT for Depression in Youth
United States160 participantsStarted 2026-02-26
Plain-language summary
The primary goal is to investigate to what extent changes in glutamate and glutathione modulation and functional integration between brain networks associated with emotion and attention regulation are associated with treatment response in mildly depressed youth.
Who can participate
Age range15 Years – 24 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
✓. age between 15 years, 0 months to 24 years, 11 months old;
✓. presenting with mild depression, defined by meeting DSM-5 criteria for a current major depressive episode, mild severity, or persistent depressive disorder, or other specified depressive disorder (depressive episode with insufficient symptoms to meet criteria for a major depressive episode);
✓. medication-naïve or medication free for at least 5 half-lives since the last use of a psychoactive medication, with the exception of stimulants for ADHD;
✓. if on ADHD stimulant medication over 2 months prior to screening, willing to maintain stimulant dose constant during the study participation;
✓. Tanner stage greater than or equal to III;
Exclusion criteria
✕. significant suicidal risk, defined by suicidal ideation of type 3, 4 or 5 on the Columbia Suicide Severity Rating Scale (C-SSRS) in the past 3 months, or any lifetime suicidal attempts;
✕. current major depressive episode, moderate or severe
✕. current or lifetime history of manic or hypomanic episodes, and/or diagnosis of bipolar disorder;
✕. current or lifetime history of psychotic disorders, and/or prior diagnosis of schizophrenia spectrum disorders;
✕. active or current substance use disorders in the last 3 months, except cannabis or alcohol use disorder, mild;
✕
What they're measuring
1
Glutamate levels in the left ventrolateral prefrontal cortex (VLPFC)