Not Yet RecruitingNot Applicable

Indirect Calorimetry Measurement in the Pediatric Intensive Care Unit's Smallest Patients

Sweden80 participantsStarted 2026-04

Plain-language summary

Indirect calorimetry is considered the reference method for measuring energy expenditure in intensive care patients. However, in infants and small children weighing less than 10 kilograms, its clinical use has historically been limited due to technical challenges related to low tidal volumes, potential increases in dead space, and measurement precision. The goal of this observational study is to evaluate the feasibility and performance of indirect calorimetry using the Q-NRG+ device in critically ill children weighing less than 10 kg who are admitted to a pediatric intensive care unit.

Who can participate

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: Newborns and infants admitted to the PICU with body weight from 0,5 up to 10 kilograms. Either requiring mechanically ventilation, with FiO2 \< 70%, PIP\<30 cmH2O and no leakage in the ventilation system. Or spontaneous breathing patients tolerating measurements with canopy. Exclusion Criteria: In mechanically ventilated patients' unstable ventilation including ventilation settings changed during the last 60 minutes (FiO2 \>70%, PIP\>30 cmH2O, or ventilation system leakage). Patients spontaneous breathing not tolerating measurements with canopy.

What they're measuring

Feasibility of Q-NRG+ indirect calorimetry measurements

Timeframe: From first enrollment until end of study (During PICU stay (Q2 2026 - Q4 2027)

Trial details

NCT IDNCT07462806

SponsorKarolinska Institutet

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2027-04

Contact for this trial

Mirjam Larsson, Ass Senior Consultant PhD stud

+46707474628 mirjam.m.larsson@regionstockholm.se

View on ClinicalTrials.gov More Pediatric Critical Illness trials