Continuous N-of-1 Computational Feasibility Study of a Whole Genome Sequence (NCT07462234) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Continuous N-of-1 Computational Feasibility Study of a Whole Genome Sequence
United States1 participantsStarted 2026-03-05
Plain-language summary
This is an observational, computational N-of-1 study that uses previously collected Whole Genome Sequencing (WGS) data from a single adult participant to evaluate the feasibility of a deterministic bioenergetic simulation model. The study does not involve clinical interventions, treatments, or prospective specimen collection. All analyses are performed on existing genomic data in a secure computational environment.
The purpose of this study is to determine whether a physics-based metabolic model can successfully integrate individual genomic constraints to generate personalized, hypothesis-driven insights about metabolic pathways. The study focuses on model feasibility and computational performance, not clinical outcomes. No medications, diets, or behavioral interventions are administered or evaluated.
Who can participate
Sex
FEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adult female participant, age 45
* Possesses previously collected 30x Whole Genome Sequencing (WGS) data
* Able to provide self-reported phenotypic and lifestyle information as needed for computational analysis
* Willing to participate in a self-directed, observational N-of-1 study
Exclusion Criteria:
* None
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Feasibility of Deterministic In Silico Metabolic Flux Simulation