Eccentric Versus Concentric Quadriceps Exercises in Knee Osteoarthritis (NCT07460466) | Clinical Trial Compass
CompletedNot Applicable
Eccentric Versus Concentric Quadriceps Exercises in Knee Osteoarthritis
Indonesia24 participantsStarted 2024-07-15
Plain-language summary
This study aims to compare the effectiveness of eccentric and concentric quadriceps femoris strengthening exercises in patients with knee osteoarthritis. Knee osteoarthritis is a common musculoskeletal condition that causes pain, reduced joint movement, muscle weakness, and functional limitations.
Participants will be assigned to perform either eccentric or concentric unilateral open kinetic chain quadriceps exercises using isotonic loading based on a 10-repetition maximum (10-RM). The exercise program will be conducted three times per week for six weeks.
The primary objective is to evaluate differences in quadriceps muscle strength between the two exercise approaches. Secondary outcomes include changes in knee range of motion and functional capacity measured using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). The results of this study are expected to provide evidence to guide exercise prescription in rehabilitation programs for patients with knee osteoarthritis.
Who can participate
Age range
40 Years – 59 Years
Sex
MALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Female participants aged 40-59 years
* Diagnosed with unilateral or bilateral knee osteoarthritis based on American College of Rheumatology (ACR) criteria and Kellgren-Lawrence grade II-III
* Knee pain lasting more than 3 months with Numeric Rating Scale (NRS) score 1-3
* Limited knee flexion range of motion
Exclusion Criteria:
* History of unstable cardiovascular, respiratory, or metabolic disease
* Knee joint instability due to cruciate or collateral ligament laxity or meniscal injury
* Previous knee surgery
* History of knee intra-articular injection within the last 3 months
* Cognitive impairment (Montreal Cognitive Assessment Indonesian Version \[MoCA-Ina\] score \< 26)
* Clinical signs of tendinopathy characterized by pain during active knee extension (open or closed kinetic chain)
* Balance disorders
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.