Postoperative Pain and Analgesic Use After Total Knee Arthroplasty (NCT07457814) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Postoperative Pain and Analgesic Use After Total Knee Arthroplasty
Czechia50 participantsStarted 2026-03-01
Plain-language summary
This prospective observational study evaluates postoperative pain intensity and analgesic consumption in patients undergoing total knee arthroplasty (TKA) under different anesthesia techniques. Patients receive either general anesthesia with peripheral nerve block, spinal anesthesia with peripheral nerve block, spinal anesthesia alone, or general anesthesia with an epidural catheter. Pain scores (NRS), analgesic use, adverse effects, patient satisfaction, and the need for therapeutic interventions are assessed during the first 48 hours after surgery. The study aims to identify differences in postoperative pain control and factors associated with hypotension and other complications.
Who can participate
Age range
18 Years – 100 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age 18-100 years
* Primary total knee arthroplasty (TKA)
* ASA physical status I-III
* Glasgow Coma Scale (GCS) score of 15
* Ability to understand study procedures and provide informed consent
* Ability to cooperate during pre-anesthetic evaluation
* No severe sensory impairment (e.g., blindness, deafness)
Exclusion Criteria:
* Revision or reoperation of TKA
* ASA score IV or higher
* Refusal to participate or inability to provide informed consent
* GCS ≤ 14
* Limited legal capacity
* Active psychiatric disorder
* Chronic use of strong opioid analgesics
* Neurological disease affecting pain perception or cooperation
* Cognitive impairment or language barrier preventing questionnaire completion
* Use of anesthesia techniques other than GA + PNB or SA + PNB (e.g., epidural anesthesia, local infiltration without PNB)
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Postoperative pain intensity
Timeframe: 6 hours, 24 hours, and 48 hours after surgery