Active — Not RecruitingNot Applicable

Metaverse Applications in Clinical Neurorehabiliation: Device Feasibility

Italy25 participantsStarted 2025-06-06

Plain-language summary

The main objective of the TERSICORE project is the development of a new advanced set of exergames in the Metaverse that can be used in all clinical and home rehabilitation devices to improve the cognitive therapy of neurological patients by exploiting the potential of social rehabilitation. Five specific exargames will be developed: a) Cooking therapy (Coordinating in a kitchen to complete a dish through shared activities); b) Escape Room (Exiting a simulated room by solving problems and logic puzzles); c) Nostalgia Bits (Sharing personal reminiscence narratives within simulated spaces); d) NeuroTeam (Mindfulness); and e) Truman Show Exploration of an urban space and role-playing. All exargames will be validated on a small population of neurological patients according to cognitive profile.

Who can participate

Age range

18 Years – 85 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria for patients: * Adult age: 18-85 years * Education: at least 5 years * Cognitive deficits at routine outpatient clinical neuropsychological assessment (at least one test with p.e. 0/1) in subjects with focal neurological insult - (post-Stroke, post-Cranial Trauma) * neurodegenerative disorders - (Multiple Sclerosis, Parkinson's, Mild Cognitive Impairment, AD-like) Exclusion criteria for patients: * Severe cognitive impairment MMSE \<22 * Presence of severe deficits in visual acuity, hearing perception, communication and severe dysmetria, such as to interfere with the administration of the activities proposed by TERSICORE * Presence of major psychiatric or neurological pathologies other than the inclusion criteria

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Feasibility: Acceptability of Intervention as assessed by TAM3 (Technology Acceptance Model 3) questionnaire.

Timeframe: Measured at discharge or 7 days post baseline

Feasibility: Perceived usability of a technological system or application as assessed by SUS (System Usability Scale)

Timeframe: Measured at discharge or 7 days post baseline

Feasibility: User experience of intervention as assessed by UEQ (User Experience Questionnaire)

Timeframe: Measured at discharge or 7 days post baseline

Feasibility: Intrinsic motivation as assessed by IMI subscale (Intrinsic Motivation Inventory).

Timeframe: Measured at discharge or 7 days post baseline

Feasibility: Sickness elicited by modern virtual reality systems as assessed by SSQ (Simulator Sickness Questionnaire).

Timeframe: Measured at discharge or 7 days post baseline

Trial details

NCT IDNCT07456475

SponsorIstituto per la Ricerca e l'Innovazione Biomedica

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-04-01

View on ClinicalTrials.gov More Neurological Disorder trials

Plain-language summary

Who can participate

Age range

18 Years – 85 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Feasibility: Acceptability of Intervention as assessed by TAM3 (Technology Acceptance Model 3) questionnaire.

Timeframe: Measured at discharge or 7 days post baseline

Feasibility: Perceived usability of a technological system or application as assessed by SUS (System Usability Scale)

Timeframe: Measured at discharge or 7 days post baseline

Feasibility: User experience of intervention as assessed by UEQ (User Experience Questionnaire)

Timeframe: Measured at discharge or 7 days post baseline

Feasibility: Intrinsic motivation as assessed by IMI subscale (Intrinsic Motivation Inventory).

Timeframe: Measured at discharge or 7 days post baseline

Feasibility: Sickness elicited by modern virtual reality systems as assessed by SSQ (Simulator Sickness Questionnaire).

Timeframe: Measured at discharge or 7 days post baseline