This prospective observational cohort study aims to evaluate the association between menstrual phase (determined by postoperative serum progesterone levels), intraoperative anesthetic consumption, and the incidence and severity of postoperative nausea and vomiting (PONV) in female patients undergoing cholecystectomy. Intraoperative anesthetic requirements will be recorded, and postoperative nausea and vomiting will be assessed using standardized scoring systems.
Who can participate
Age range
18 Years – 65 Years
Sex
FEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Female patients aged 18 to 65 years
* American Society of Anesthesiologists (ASA) physical status I-II-III
* Scheduled for elective laparoscopic cholecystectomy under general anesthesia
* Willing and able to provide written informed consent
Exclusion Criteria:
* Age outside the specified range (younger than 18 or older than 65 years)
* Male patients
* American Society of Anesthesiologists (ASA) physical status ≥ IV
* Severe systemic comorbidities (e.g., significant cardiovascular, hepatic, renal, or pulmonary disease)
* Conversion from laparoscopic to open cholecystectomy
* History of alcohol, drug, or substance abuse
* Visual or hearing impairment interfering with study assessments
* Current hormone replacement therapy
* Use of oral contraceptives
* Preoperative nausea or vomiting
* History of severe postoperative nausea and vomiting
* Neurological or psychiatric disorders affecting assessment reliability
* Hemodynamic instability during surgery
* Postoperative admission to intensive care unit
* Acute cholecystitis at the time of surgery
* Refusal to participate or inability to provide informed consent
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Intraoperative Anesthetic Agent Consumption
Timeframe: From induction of anesthesia to the end of surgery