CompletedNot Applicable

Impact of NR3C1 rs41423247 (BclI) Polymorphism on Disease Severity in Alopecia Areata

Egypt120 participantsStarted 2023-11-01

Plain-language summary

Alopecia areata is an autoimmune, non-scarring hair loss disorder with multifactorial pathogenesis. The glucocorticoid receptor gene (NR3C1) plays an essential role in immune regulation and inflammatory response. The rs41423247 polymorphism (BclI) may influence glucocorticoid sensitivity and disease activity. This study aims to investigate the association between NR3C1 rs41423247 polymorphism and susceptibility to alopecia areata and to evaluate its correlation with disease severity using the Severity of Alopecia Tool (SALT) score.

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria (Cases): * Clinically diagnosed alopecia areata * Age ≥ 18 years * Both sexes * Willingness to participate and provide informed consent Inclusion Criteria (Controls): * Apparently healthy individuals * No history of autoimmune disease * Age- and sex-matched to cases * Provided informed consent Exclusion Criteria: * Presence of other autoimmune or inflammatory diseases * Current systemic immunosuppressive therapy * Pregnancy or lactation * Refusal to participate

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Distribution of NR3C1 rs41423247 Genotypes and Alleles

Timeframe: Baseline

Trial details

NCT IDNCT07455708

SponsorBenha University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2024-11-01

View on ClinicalTrials.gov More Alopecia Areata(AA) trials