Effect Of Different Sodium Hypochlorite Concentrations On Intracanal Substance P, CGRP And Opiorp… (NCT07453576) | Clinical Trial Compass
RecruitingNot Applicable
Effect Of Different Sodium Hypochlorite Concentrations On Intracanal Substance P, CGRP And Opiorphin Levels And Postoperative Pain During Root Canal Retreatment
Turkey (Türkiye)60 participantsStarted 2025-10-01
Plain-language summary
This randomized clinical study aims to evaluate the effect of different sodium hypochlorite concentrations (1%, 2.5%, and 5.25%) used during root canal retreatment on intracanal levels of Substance P, CGRP, and Opiorphin, as well as postoperative pain.
Patients requiring non-surgical root canal retreatment will be randomly assigned to one of three irrigation concentration groups. Intracanal samples will be collected before and after irrigation to measure neuropeptide levels. Postoperative pain will be assessed using a visual analog scale (VAS) at predetermined time intervals.
The results of this study may help clarify the relationship between irrigant concentration, inflammatory mediators, and postoperative pain following root canal retreatment.
Who can participate
Age range
18 Years – 65 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patients aged between 18 and 65 years.
* Systemically healthy individuals (ASA I or II)
* Patients requiring non-surgical root canal retreatment of a previously treated permanent tooth
* Patients who provide written informed consent.
Exclusion Criteria:
* Patients with systemic diseases that may affect pain perception or inflammatory response.
* Use of analgesics, anti-inflammatory drugs, or antibiotics within 7 days prior to treatment.
* Pregnant or lactating women.
* Teeth with root fractures, perforations, advanced periodontal disease, or non-restorable teeth.
* Teeth with open apices or immature root development.
* Presence of acute apical abscess with swelling or sinus tract.
* Patients with known allergy to sodium hypochlorite.
* Inability to achieve adequate isolation with rubber dam.
* Patients unable to attend follow-up or complete pain assessment forms.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in Intracanal Substance P, CGRP, and Opiorphin Levels
Timeframe: Before irrigation and immediately after irrigation during the same treatment session
2
Change in Intracanal Substance P, CGRP, and Opiorphin Levels
Timeframe: Before irrigation and immediately after irrigation during the same treatment session