3D Ultrasound in Hemophilic Ankles (NCT07452575) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
3D Ultrasound in Hemophilic Ankles
11 participantsStarted 2026-04-01
Plain-language summary
The study examines whether a mechanical arm ultrasound system provides diagnostic accuracy comparable to expert-performed full ultrasound for detecting key joint components and whether it can reduce acquisition variability without compromising accuracy, as measured by false-positive and false-negative rates.
Who can participate
Age range
5 Years – 18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Diagnosis of hemophilia A or B or other bleeding disorders
* Cooperative patients
* Previous study joint bleed (by history) or suspicion of an acute joint bleed
Exclusion Criteria:
* Co-morbid chronic illnesses causing osteoarticular findings
* MRI contraindications
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial is comparing 3D ultrasound against standard ultrasound and MRI for detecting ankle joint damage in hemophilia — how does my ankle currently look on those existing imaging methods, and would joining a study like this give me any additional insight into my joint health?
2Since this trial is listed as 'not yet recruiting,' how far off might it realistically be before it opens, and is it worth waiting to see if I'm eligible, or should we focus on monitoring my ankles through currently available imaging right now?
3The study is measuring things like synovial hypertrophy, hemosiderin deposits, and cartilage loss in the ankle — are any of those changes already a concern for me, and how would earlier or more detailed detection of them actually change my treatment plan?
4This appears to be a diagnostic imaging study rather than a treatment trial — does that mean there's no change to my hemophilia therapy if I participate, and what exactly would be asked of me in terms of scans or visits?
5If 3D ultrasound turns out to be as accurate as MRI for tracking hemophilic ankle damage, how might that affect how my joints are monitored long-term, and is my care team already using any advanced imaging to watch for early signs of joint deterioration?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
1. Diagnostic Accuracy of 3DUS compared with full ultrasound and MRI
Timeframe: Day 1
2
Ability of 3DUS to quantify individual joint components (synovial hypertrophy, hemarthrosis, hemosiderin, bone erosions/subchondral cysts, cartilage loss)