Effectiveness of TMS on Spasticity and Balance for Patients With MS (NCT07451600) | Clinical Trial Compass
RecruitingNot Applicable
Effectiveness of TMS on Spasticity and Balance for Patients With MS
Turkey (Türkiye)24 participantsStarted 2026-03-01
Plain-language summary
Recently, non-invasive brain stimulation modalities such as transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation have become treatment options. Among these methods, rTMS is a non-invasive brain stimulation technique that can affect descending corticospinal pathways, thereby modulating cortical excitability in the motor area where it is applied. This study will examine the effect of rTMS application on spasticity and balance in patients with multiple sclerosis. In addition, the indirect effects of the applications on gait pattern, joint range of motion, and pain will be evaluated.
Who can participate
Age range
18 Years – 60 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Being between the ages of 18 and 60
* Having been diagnosed with multiple sclerosis for more than six months
* Having spasticity levels between 1 and 3 on the Modified Ashworth Scale (MAS) in the evaluated extremity
* Having an EDSS SCORE between 0 and 6.5
* Voluntarily participating in the study
Exclusion Criteria:
* Poor general health (heart failure, COPD, etc.)
* Presence of wound lesions on the skin
* Presence of metal implants in the body
* Pregnancy
* Presence of a severe infection
* Diagnosis of malignancy
* Presence of a bleeding disorder
* Use of a pacemaker
* Presence of cardiac rhythm disorder
* Presence of neurological disease other than multiple sclerosis
* History of epilepsy
* History of alcohol use
* Change in medication within the last 6 months
* Refusal to participate in the study
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Modified Ashworth Scale
Timeframe: patients will be checked on first day of hospitalization, after treatment at 2 weeks and after treatment 1 month
2
Penn Spasm Frequency Scale
Timeframe: patients will be checked on first day of hospitalization, after treatment at 2 weeks and after treatment 1 month
3
Modified Tardieu Scale
Timeframe: patients will be checked on first day of hospitalization, after treatment at 2 weeks and after treatment 1 month
4
BERG Balance Scale
Timeframe: patients will be checked on first day of hospitalization, after treatment at 2 weeks and after treatment 1 month
5
Goal Attainment Scale
Timeframe: patients will be checked on first day of hospitalization and after treatment 1 month