RecruitingNot Applicable

Effectiveness of TMS on Spasticity and Balance for Patients With MS

Turkey (Türkiye)24 participantsStarted 2026-03-01

Plain-language summary

Recently, non-invasive brain stimulation modalities such as transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation have become treatment options. Among these methods, rTMS is a non-invasive brain stimulation technique that can affect descending corticospinal pathways, thereby modulating cortical excitability in the motor area where it is applied. This study will examine the effect of rTMS application on spasticity and balance in patients with multiple sclerosis. In addition, the indirect effects of the applications on gait pattern, joint range of motion, and pain will be evaluated.

Who can participate

Age range18 Years – 60 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Being between the ages of 18 and 60 * Having been diagnosed with multiple sclerosis for more than six months * Having spasticity levels between 1 and 3 on the Modified Ashworth Scale (MAS) in the evaluated extremity * Having an EDSS SCORE between 0 and 6.5 * Voluntarily participating in the study Exclusion Criteria: * Poor general health (heart failure, COPD, etc.) * Presence of wound lesions on the skin * Presence of metal implants in the body * Pregnancy * Presence of a severe infection * Diagnosis of malignancy * Presence of a bleeding disorder * Use of a pacemaker * Presence of cardiac rhythm disorder * Presence of neurological disease other than multiple sclerosis * History of epilepsy * History of alcohol use * Change in medication within the last 6 months * Refusal to participate in the study

What they're measuring

Modified Ashworth Scale

Timeframe: patients will be checked on first day of hospitalization, after treatment at 2 weeks and after treatment 1 month

Penn Spasm Frequency Scale

Timeframe: patients will be checked on first day of hospitalization, after treatment at 2 weeks and after treatment 1 month

Modified Tardieu Scale

Timeframe: patients will be checked on first day of hospitalization, after treatment at 2 weeks and after treatment 1 month

BERG Balance Scale

Timeframe: patients will be checked on first day of hospitalization, after treatment at 2 weeks and after treatment 1 month

Goal Attainment Scale

Timeframe: patients will be checked on first day of hospitalization and after treatment 1 month

Trial details

NCT IDNCT07451600

SponsorAnkara Etlik City Hospital

Sponsor typeOTHER_GOV

Study typeINTERVENTIONAL

Primary completion2026-10-31

Contact for this trial

Melike Çil, specialist

+90 0312 797 00 00 melike9671@gmail.com

View on ClinicalTrials.gov More Multiple Sclerosis trials

Plain-language summary

Who can participate

Age range18 Years – 60 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Modified Ashworth Scale

Timeframe: patients will be checked on first day of hospitalization, after treatment at 2 weeks and after treatment 1 month

Penn Spasm Frequency Scale

Timeframe: patients will be checked on first day of hospitalization, after treatment at 2 weeks and after treatment 1 month

Modified Tardieu Scale

Timeframe: patients will be checked on first day of hospitalization, after treatment at 2 weeks and after treatment 1 month

BERG Balance Scale

Timeframe: patients will be checked on first day of hospitalization, after treatment at 2 weeks and after treatment 1 month

Goal Attainment Scale

Timeframe: patients will be checked on first day of hospitalization and after treatment 1 month