Not Yet RecruitingNot Applicable

SII Levels Following iPACK Block With Adductor Canal Block in Knee Arthroplasty

Poland60 participantsStarted 2026-04-01

Plain-language summary

This randomized controlled trial evaluates the effect of ultrasound-guided iPACK block with Adductor Canal Block (ACB) on the Systemic Immune-Inflammation Index (SII) in elderly patients undergoing total hip arthroplasty under spinal anesthesia. SII, calculated as platelet × neutrophil / lymphocyte count, is used as a composite marker of perioperative inflammatory and immune response. The study investigates whether iPACK block with ACB attenuates the systemic inflammatory reaction to surgical trauma compared to sham block.

Who can participate

Age range65 Years – 100 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients with ASA classification I-III * Aged 65-100 years * Who will be scheduled for hip arthroplasty under spinal anesthesia Exclusion Criteria: * Patients who have a history of bleeding diathesis * Take anticoagulant therapy * History of chronic pain before surgery * Multiple trauma * patients unable to assess their pain (dementia) * patients operated under general anesthesia * patients having an infection in the region of the procedure * the patient who does not accept the procedure

What they're measuring

Systemic Inflammation Response Index (SIRI)

Timeframe: 12 hours after surgery

Trial details

NCT IDNCT07449442

SponsorPoznan University of Medical Sciences

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-05-31

Contact for this trial

Malgorzata Reysner, MD PhD

+48 501 056 924 mreysner@ump.edu.pl

View on ClinicalTrials.gov More Knee Osteoarthritis trials