Diode Laser Plus CPP-ACPF vs CPP-ACPF Alone for Dentin Hypersensitivity (NCT07449169) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Diode Laser Plus CPP-ACPF vs CPP-ACPF Alone for Dentin Hypersensitivity
70 participantsStarted 2026-04-01
Plain-language summary
This study aims to compare the effectiveness of diode laser photobiomodulation combined with CPP-ACPF varnish versus CPP-ACPF varnish alone in reducing dentin hypersensitivity. Participants diagnosed with dentin hypersensitivity will receive either the combined treatment or varnish application alone. Pain levels will be evaluated using a standardized visual analog scale before and after treatment sessions. The results of this study may help determine whether adding diode laser therapy enhances the effectiveness of conventional varnish treatment in managing dentin hypersensitivity.
Who can participate
Age range
20 Years – 50 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adult participants aged from 20 to 50 years of age.
* Participants with good oral hygiene.
* Presence of at least one tooth with dentin hypersensitivity confirmed by the air blast and/or tactile stimuli (scoring ≥3 on the VAS).
* Participants willing to cooperate and attend recall appointments
* Teeth with Non-Carious Cervical Lesions.
* Patients with dentin hypersensitivity due to GERD and Parafunctional habits e.g., bruxism.
* Patients with dentin hypersensitivity associated with gingival recession.
Exclusion Criteria:
* Participants with poor oral hygiene.
* History of professional or at-home desensitizing treatment within the previous 3 months.
* Pregnant or lactating females.
* Concurrent participation in other research studies.
* Inability to comply with study procedures.
* History of allergic reactions to study materials.
* Medical conditions interfering with pain reporting accuracy (pain disorders, constant use of analgesics, anti-inflammatory, or psychotropic medications).
* History of periodontal surgeries within the last six months.
* Periodontitis and pulpitis.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Reduction in dentin hypersensitivity in response to evaporative (air-blast) stimulus
Timeframe: Assessed at baseline, immediately post-treatment, and at 1 month, 3 months, and 6 months follow-up.