Evaluation of the Efficacy of Oral Tranexamic Acid and Glutathione-assisted Microneedling in Treatment of Melasma

Inclusion Criteria: * • female patients * 18/50 years old * facial melasma Exclusion Criteria: * pregnancy * lactation. * History of any bleeding, * clotting disorder * using anticoagulants * Chronic systemic diseases * patients with history of atypical parkinsonism * use of neuroleptics, * history of a seizure * drug addiction * Patients with signs of facial inflammation or infection. * Patients on oral contraceptive pills * patients with hormonal replacement therapy * patients on isotretinoin at the time of the study or during the past 6 months.