CompletedPhase 2

Vasopressin vs. Uterine Artery Clamping for Laparoscopic Cesarean Scar Niche Repair

Saudi Arabia30 participantsStarted 2024-03-20

Plain-language summary

This study evaluates two methods for controlling intraoperative bleeding during laparoscopic surgery to repair a cesarean scar niche (CSN). It compares the effectiveness of intramyometrial vasopressin injection against bilateral temporary clamping of the uterine arteries using laparoscopic bulldog clips. The goal is to determine if vasopressin injection is non-inferior to arterial clamping in reducing blood loss and maintaining surgical field visibility.

Who can participate

Age range21 Years – 45 Years

SexFEMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Diagnosis of symptomatic CSN. * Scheduled for laparoscopic excision and repair. Exclusion Criteria: * Contraindications to vasopressin (e.g., severe hypertension or cardiovascular disease). * Presence of other major uterine pathologies (e.g., large myomas or malignancy).

What they're measuring

Mean Hemoglobin Deficit Mean Hemoglobin Deficit

Timeframe: 24 hours post-surgery.

Trial details

NCT IDNCT07446933

SponsorZagazig University

Sponsor typeOTHER_GOV

Study typeINTERVENTIONAL

Primary completion2025-10-17

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