Magnesium vs. Dexmedetomidine in TURBT Under Spinal Anesthesia (NCT07445451) | Clinical Trial Compass
CompletedNot Applicable
Magnesium vs. Dexmedetomidine in TURBT Under Spinal Anesthesia
Turkey (Türkiye)93 participantsStarted 2024-12-15
Plain-language summary
This randomized controlled trial evaluated the effects of intraoperative intravenous magnesium sulfate versus dexmedetomidine on postoperative pain, analgesic consumption, hemodynamic stability, and respiratory function in patients undergoing elective transurethral resection of bladder tumor (TUR-M) under spinal anesthesia. Magnesium sulfate significantly reduced postoperative pain scores, delayed the time to first analgesic request, and decreased total analgesic consumption compared to dexmedetomidine and control groups, while both agents were hemodynamically and respiratorily safe.
Who can participate
Age range
18 Years – 85 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
Age between 18 and 85 years. Classified as ASA physical status I, II, or III according to the American Society of Anesthesiologists.
Patients scheduled for elective transurethral resection of bladder tumor (TUR-M) under spinal anesthesia.
Exclusion Criteria:
Patients under 18 years or over 85 years of age. Contraindications to spinal anesthesia (e.g., infection at puncture site, coagulopathy).
History or current diagnosis of significant cardiac arrhythmia. Known allergy or contraindication to the study drugs (magnesium sulfate or dexmedetomidine).
Patients requiring conversion to general anesthesia due to inadequate spinal anesthesia intraoperatively.
Mental retardation, cognitive impairment, or communication difficulties that prevent understanding of study procedures or pain assessment.
Patients who refuse to participate in the study.
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Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Time to First Analgesic Request
Timeframe: Postoperative period up to 24 hours
2
Total Postoperative Analgesic Consumption
Timeframe: 24 hours postoperative
3
Postoperative Pain Scores
Timeframe: 24 hours postoperative
Trial details
NCT IDNCT07445451
SponsorDr. Lutfi Kirdar Kartal Training and Research Hospital