CompletedNot Applicable

10-Year Survival After Acute Hip Fracture in Patients With Preclinical/Clinical Alzheimer Pathology

Sweden404 participantsStarted 2013-10

Plain-language summary

This study is a 10-year follow-up of a previously enrolled cohort of patients who underwent surgery for acute hip fracture with spinal anesthesia and had pre-fracture cognitive status assessed (Clinical Dementia Rating, CDR) and cerebrospinal fluid (CSF) biomarkers related to Alzheimer's disease measured (e.g., Aβ42/Aβ40 ratio, total tau, phosphorylated tau). The primary aim is to determine long-term survival at 10 years after index hip fracture surgery and to evaluate whether baseline cognitive status and/or Alzheimer-type CSF biomarker profiles are associated with long-term mortality.

Who can participate

Age range65 Years

SexALL

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Inclusion Criteria: * Participant enrolled in the original acute hip fracture cohort (index surgery during Oct 2013-Jun 2015 at Sahlgrenska University Hospital, Mölndal) * Available personal identity number enabling linkage to Swedish registries * Baseline cognitive assessment (CDR) and/or CSF biomarker data available from the index admission Exclusion Criteria: Missing linkage information preventing ascertainment of vital status \-

What they're measuring

All-cause mortality / survival at 10 years after index hip fracture surgery

Timeframe: up to 10 years post-surgery

Trial details

NCT IDNCT07443566

SponsorBengt Nellgård

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2015-06

View on ClinicalTrials.gov More Hip Fractures (ICD-10 72.01-72.2) trials