CompletedNot Applicable

Non-Invasive Brain Stimulation as Add-on Treatment in Chronic Migraine With Medication Overuse

Italy60 participantsStarted 2024-01-02

Plain-language summary

This randomized, double-blind, sham-controlled clinical trial aims to evaluate the efficacy of non-invasive brain stimulation as an add-on treatment to standard detoxification therapy in patients with chronic migraine and medication overuse. The study also seeks to identify sensory and biochemical biomarkers predictive of treatment response.

Who can participate

Age range18 Years – 80 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Diagnosis of chronic migraine and medication overuse according to ICHD-3 criteria * Ability to provide written informed consent Exclusion Criteria: * Major psychiatric disorders (e.g., major depressive disorder) * Changes in preventive migraine therapy within the last 3 months * Ongoing treatment with monoclonal antibodies for migraine prevention * Other significant neurological or systemic diseases * Pregnancy * Contraindications to transcranial magnetic stimulation (for main study participants)

What they're measuring

Number of monthly days with moderate-to-severe headache

Timeframe: 1 month post-treatment

Trial details

NCT IDNCT07442916

SponsorIRCCS National Neurological Institute "C. Mondino" Foundation

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-01-30

View on ClinicalTrials.gov More Chronic Migraine trials