Active — Not RecruitingNot Applicable

AGECTO Study: PCI vs. Optimal Medical Therapy for CTO in the Octogenarian Patients

Italy200 participantsStarted 2025-07-01

Plain-language summary

The study compares an interventional strategy (PCI) with optimal medical therapy (OMT) in ultra-octogenarians with chronic total occlusions (CTO). Results suggest that successful PCI leads to significant improvements in symptoms and quality of life compared to OMT alone. While initially carrying higher procedural risks, CTO-PCI is considered feasible and safe in experienced centers. There is also potential for long-term benefits in survival and a reduction in major adverse cardiovascular events (MACE). The choice between treatments depends on an individual risk-benefit assessment, considering the patient's overall condition.

Who can participate

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age ≥ 80 years. * CTO in at least one major coronary artery. * Complete revascularization or non-critical stenosis in the non-CTO vessels. * Life expectancy \> 1-year Exclusion Criteria: * Severe non-cardiac comorbidities with a life expectancy \< 1 year. * CTOs in the native vessel and patency grafts in CABG patients * CTOs in the minor vessel (Non dominant RCA, small diagonal or obtuse marginal branch) * Lack of any anatomical or clinical details of the patient

What they're measuring

MACE (Major Cardiovascular Events)

Timeframe: From enrollment to 1-year

Trial details

NCT IDNCT07442526

SponsorSan Luigi Gonzaga Hospital

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2025-09-01

View on ClinicalTrials.gov More Coronary Artery Disease (CAD) trials