Accelerated and Extended-iTBS Targeting Inhibitory Control in Veterans With ADHD (NCT07442058) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Accelerated and Extended-iTBS Targeting Inhibitory Control in Veterans With ADHD
United States35 participantsStarted 2026-10-01
Plain-language summary
Impaired inhibitory response manifests clinically as increased impulsivity, which leads to poorer affective, cognitive, social, and occupational functioning. Neuropsychiatric disorders prevalent among Veterans, such as Attention Deficit/Hyperactivity Disorder (ADHD), are associated with poor inhibitory control. The mainstay of clinical treatment for ADHD is psychostimulants, yet these medications have significant risks, including dependence and numerous side effects. Thus, novel and non-pharmacological therapeutic strategies are needed. Intermittent Theta Burst Stimulation, a newer form of transcranial magnetic stimulation, has emerged as a promising tool for modulating inhibitory neuronal circuits. This research proposal will investigate the feasibility and acceptability of iTBS on inhibitory control and impulsivity through a randomized controlled trial to inform clinical observations. The long-term goal is to improve impulsivity, social and occupational functioning, and enhance the quality of life for Veterans.
Who can participate
Age range
18 Years – 65 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Diagnosis of ADHD predominantly hyperactive-impulsive or combined, as outlined in the DSM-5-TR criteria
* Maintenance of clinical symptoms despite receiving stable treatment for a minimum of 6 weeks before the study procedures
* Capability to comprehend and provide informed consent
* For safety reasons, participants must meet established screening criteria to ensure safety during Magnetic Resonance Imaging (MRI) scans
* This precaution is taken due to the novel application of iTBS in this specific population, as MRI involves exposure to magnetic fields similar in intensity to those emitted from the stimulation coil
* As such, participants must not have the following, unless the devices are MRI-safe:
* cardiac pacemaker
* implanted devices (such as deep brain stimulators)
* metal in the brain
* cervical spinal cord, or upper thoracic spinal cord level
* In addition, eligible Veterans must also be able and willing to comply with all study procedures and visits
* Throughout the study, pharmacologic and psychotherapeutic regimens will tentatively remain unchanged
Exclusion Criteria:
* Primary psychotic disorders, bipolar I disorder, ongoing severe substance use disorders, or active suicidality
* Non-MRI safe cardiac pacemakers, implanted devices, or metallic implants at the upper thoracic spine level or higher
* Any of the Transcranial Magnetic Stimulation (TMS) specific exclusion criteria, including:
* pregnancy
* lactation
* planning …
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial is listed as 'not yet recruiting' — do you know when it's expected to open, and would it make sense for me to get on a waitlist or check back at a specific time?
2The trial's main goals are to measure feasibility and acceptability — meaning it's focused on whether the treatment is practical and tolerable rather than proving it works — so how does that affect what I might personally gain from participating compared to starting a standard ADHD treatment now?
3The study uses a brain stimulation technique called iTBS targeting inhibitory control in veterans with ADHD — am I the right kind of patient for this, given my specific history and how my ADHD presents?
4The trial measures success partly by how consistently participants attend stimulation sessions — given my schedule and where this would be located, is that level of commitment realistic for my situation?
5Since this is listed as Phase NA and is primarily a feasibility study, what is currently known about the safety of this type of brain stimulation for ADHD, and are there any risks I should weigh against trying a more established treatment first?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Feasibility measured by follow-up completion
Timeframe: 6 weeks
2
Acceptability measured by stimulation sessions attendance